Endocrine Abstracts

Objective: Transgender persons often experience low socioeconomic status. Gender affirming treatment aims to improve gender dysphoria. We assessed employment rates in transgender persons compared to controls and demographic, health and treatment-related factors associated with unemployment in transgender persons.Methods: National register-based cohort study in Danish transgender persons with diagnosis code of gender identity disorder during year 2000-202...

Background: Although polycystic ovary syndrome (PCOS) constitutes a common endocrinopathy, there are several issues which confuse clinicians during everyday practice.Objective: To define the current status of knowledge of the full spectrum of PCOS among European endocrinologists.Methods: A detailed questionnaire comprising 41 items covering various aspects of diagnosis and management of women with PCOS was shared via web among memb...

Background: Maternal free testosterone (FT) increases during 3rd trimester pregnancy and FT levels are higher in women with polycystic ovary syndrome (PCOS) compared to controls. Fetal exposure to maternal FT during 3rd trimester was associated with lower weight, length and shorter abdominal circumference at birth, in boys. Furthermore, lower birth weight has been related to higher abdominal fat mass in young children.Aim: To examine associations between...

Background: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Guidelines regarding treatment algorithms and follow-up vary considerably.Aim: To evaluate consensus on the treatment and follow-up of acromegaly in the Scandinavian countries.Methods: To map the landscape of acromegaly management in the Scandinavian countries, ...

Patients on long term glucocorticoid replacement therapy have higher rates of morbidity and mortality. One causative factor may be non-physiological cortisol replacement. We have developed as part of the ULTRADIAN consortium (https://www.uib.no/en/ultradian) the U-RHYTHM, an ambulatory bio-sampling device that can collect clinical samples using in-vivo microdialysis every 20 minutes over the 24hour day whilst individuals continue with their normal everyday activities....

Background: The safety and efficacy of telotristat ethyl (TE) in patients (pts) with metastatic neuroendocrine tumors (NETs) and carcinoid syndrome (CS) not adequately controlled with somatostatin analogs (SSAs) have been demonstrated. TE-treated pts showed significantly greater reductions in bowel movement (BM) frequency and more presented with durable response than placebo (PBO)-treated pts. These post-hoc analyses examined the relationship between improvements in symptoms a...

Context: Individualized fracture risk may help to select patients requiring a pharmacological treatment for osteoporosis. FRAX and the Garvan fracture risk calculators are the most used tools, though their external validation has shown significant differences in their risk prediction ability.Objective and Methods: Using data from the FRISBEE study, a cohort of 3560 post-menopausal women aged 60-85 years, we aimed to construct original 5-year fracture ris...

Objective: Hypothalamic obesity results in severe weight-gain and increased risk of cardiovascular and metabolic mortality. We aimed to assess the safety and efficacy of Tesomet (tesofensine plus metoprolol), and ongoing requirements in pituitary hormone replacement adjustments in adults with acquired hypothalamic obesity, a rare disease with no approved therapyResearch design, patients and methodsTwenty-one adults with hypothalami...

Background: Perfluoroalkyl substances (PFAS) are endocrine disrupting chemicals, with elimination half-lives ranging from four to eight years. Experimental studies found PFAS able to interfere with thyroid hormone-binding proteins. During the first 20 weeks of gestation (GW), the fetus is reliant on placental transfer of maternal thyroid hormones, mainly free thyroxine (FT4). However, previous studies investigating associations between exposure to PFAS and thyroid hormone stat...

Background: Prolactin is associated with metabolic risk inside and outside of pregnancy. Maternal prolactin levels could be associated with offspring body composition.Aim: To investigate if maternal prolactin-levels were linked to offspring body composition at seven years of age.Design: Prospective observational cohort study (the Odense Child Cohort).Methods: Maternal fasting blood samples were assessed durin...